Job 12:21

He poureth contempt upon princes
Not on good princes, such as rule in righteousness, and decree judgment and govern their subjects according to good laws, in a mild and gentle manner, and answer to their name of free, liberal, beneficent and munificent. These, as there is an honour due unto them, it is the will of God they should have it; much less are princes, in a figurative sense, meant, good men, the children of God, who are born of him the King of kings, and so princes in all the earth; but, in a literal sense, bad princes, that oppress their subjects, and rule them with rigour, and persecute good men; such as rose up against Christ, as Herod and Pontius Pilate; persecutors of the saints, as the Roman emperors, and the antichristian princes in the papacy; these God sometimes brings into contempt with their subjects, deposes them from their government, reduces them to a mean, abject, and servile state; or they die a shameful death, as Herod was eaten with worms, and many of the Heathen emperors died miserable deaths; and the vials of God's wrath will be poured out upon all the antichristian states, and their princes: pouring denotes the abundance of shame they are put to, as if they were clothed and covered with it, it being plentifully poured out like water, or as water was poured upon them, which is sometimes done by way of contempt, see ( Psalms 107:40 ) ;

and weakeneth the strength of the mighty;
the strength of men, hale and robust, by sending one disease or another upon them, which takes it away from them; or by "the mighty" are meant men in power and authority; kings, as the Targum paraphrases it, mighty monarchs, whose strength lies in their wealth and riches, in their fortresses and powerful armies; all which God can deprive them of in an instant, and make them as weak as other men. Some render it, "and looseneth the girdle of the mighty" ^F2, the same as loosening the loins of kings, ( Isaiah 14:1 ) ; ungirding them, and taking away their power and authority from them, rendering them unfit for business, or unable to keep their posts and defend their kingdom.